Use the links below to find the ART families or clades specified.
R-[ST]-E clade: This active site configuration is found in bacterial toxins and in some eukaryotic intracellular and extracellular ART. In this clade, arginine plays the same role as histidine in strand 1, and serine and threonine play a role comparable to tyrosine in strand 2. The glutamic acid of strand 5 has an identical function to the analogous residue in those with an H-Y-E active site. Two subclades are separated in the RSE clade. One is formed by domains having structures with 6 beta-strands and the other by domains with 7 beta-strands. Formerly, the clade RSE domains were called ARTCs.
H-Y-[QED] clade: This active site configuration occurs in intragenomic conflict systems (e.g., type II toxin-antitoxin (T-A) systems) . In the active site, histidine from strand 1 occurs in the same motif as observed in the H-H-h clade. An aromatic residue (tyrosine, less commonly phenylalanine) is present in strand 2. The residue found at the beginning of strand 5 is acidic or, in some cases, is glutamine. Formerly, the clade HYE domains were called ARTDs.
H-H-h clade: is considered the most primary ART clade. It includes two major families: the PTS_2-RNA (also known as the KptA (ARTD18) family or the phosphotransferase 2′ tRNA family) and the DUF952 family. In this clade, the active site is composed of two histidines (from the first and second strands) and a hydrophobic residue (h) from strand 5.
| Lqui_0088 |
| PTS_2-RNA |
| DUF952 |
EvpP clade: one of the so-called "aberrant clades". It consists of families of toxin tips of polymorphic toxins: NTox40, NTox46 and NTox48 and effectors of pathogenic bacteria. It is unclear whether it is a derived clade from other known clades or an independent transitional clade.
| Ntox40 |
| TNT |
Ntox31 clade: one of the so-called "aberrant clades". ARTs from the Ntox31 clade occur in polymorphic arrangements of toxins and SNPs.
| Ntox31 |