ART Database

ART family found in Proteobacteria and in Mucoromycota. Inhibits eukaryotic protein synthesis by modifying elongation factor-2.

Prokaryotic exotoxin A catalyses the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, with subsequent inhibition of protein synthesis [PUBMED:8692916].

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Source: Pfam 34.0, rp75 Number of sequences: 10 Average length of the domain: 143 aa HMM: Model length: 162 Clustering level: 80% Alignment: ClustalO Additional information: sequences longer than 50 amino acids