ART Database

ADP-ribosyltransferase actin TccC3 is a toxin from entomopathogenic bacteria - Photorhabdus, Xenorhabdus and Serratia. It is the only enzyme that interacts with two consecutive subunits of actin F-actin by modifying it at T148 (rather than with G-actin at R177). This site-specific modification of F-actin prevents its interaction with depolymerization factors, e.g., cofilin, which impairs actin network turnover and leads to permanent actin polymerization. Thus, it effectively disrupts the regulation of the actin cytoskeleton, with serious consequences for the host.