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ART Database

CLADE: R-S-E (ARTC000001)

FAMILY: AvrPphF-ORF-2 (ARTF000009)

Description

Family from Pseudomonas syringae pv. phaseolicola, the causative agent of bean halo-blight disease. Members of this family of plant pathogenic proteins adopt an elongated structure somewhat reminiscent of a mushroom that can be divided into 'stalk' and 'head' subdomains. The head subdomain possesses weak structural similarity with the catalytic part of a number of ADP-ribosyltransferase toxins.

InterPro - IPR015226

Members of this family of plant pathogenic proteins adopt an elongated structure somewhat reminiscent of a mushroom that can be divided into 'stalk' and 'head' subdomains. The stalk subdomain is composed of the N-terminal helix (alpha1) and beta strands beta3-beta4. An antiparallel beta sheet (beta5, beta7-beta8) forms the base of the head subdomain that interacts with the stalk. A pair of twisted antiparallel beta sheets (beta1 and beta6; beta2 and beta9/9') supported by alpha2 form the dome of the head. The head subdomain possesses weak structural similarity with the catalytic portion of a number of ADP-ribosylt ransferase toxins [PUBMED:15341731]. Many Gram-negative pathogenic bacteria directly translocate effector proteins into eukaryotic host cells via a type III secretion system. Type III effector proteins are determinants of virulence on susceptible plant hosts; they are also the proteins that trigger specific disease resistance in resistant plant hosts. Evolution of type III effectors is dominated by competing forces: the likely requirement for conservation of virulence function, the avoidance of host defenses, and possible adaptation to new hosts.

Sequences
Aligned domain sequences
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Unaligned domain sequences
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Full sequences
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Structures

Name Structure Additional informations
1S21 Download structure Reference structure
Literature
  • PMID: 15341731
  • Origin

    Source: Pfam 34.0, rp75 Number of sequences: 27 Average length of the domain: 155 aa HMM: Model length: 170 Clustering level: 80% Alignment: ClustalO Additional information: sequences longer than 50 amino acids