× Description Interpro WebLogo Sequences HMM Model Structures Origin
☰ Sections

ART Database

CLADE: H-Y-E (ARTC000002)

FAMILY: Enterotoxin_a (ARTF000025)

Description

ART family including Escherichia coli heat-labile toxin and cholera toxin secreted by Vibrio cholerae. These toxins are composed of A and B subunits – the enzymatic activity of ADP-ribosyltransferase has the A subunit.

InterPro - IPR001144

Escherichia coli heat-labile enterotoxin is a bacterial protein toxin with an AB5 multimer structure, in which the B pentamer (INTERPRO) has a membrane-binding function and the A chain is needed for enzymatic activity [PUBMED:8478941]. The B subunits are arranged as a donut-shaped pentamer, each subunit participating in ~30 hydrogen bonds and 6 salt bridges with its two neighbours [PUBMED:8478941]. The A subunit has a less well-defined secondary structure. It predominantly interacts with the pentamer via the C-terminal A2 fragment, which runs through the charged central pore of the B subunits. A putative catalytic residue in the A1 fragment (Glu112) lies close to a hydrophobic region, which packs two loops together. It is thought that this region might be important for catalysis and membrane translocation [PUBMED:8478941].

Sequences
Aligned domain sequences
Download sequence
Unaligned domain sequences
Download sequence
Full sequences
Download sequence
Structures

Name Structure Additional informations
2A5D Download structure Reference structure
2A5G Download structure Reference structure
1S5C Download structure Reference structure
1S5B Download structure Reference structure
1S5D Download structure Reference structure
1S5F Download structure Reference structure
1S5E Download structure Reference structure
2A5F Download structure Reference structure
1XTC Download structure Reference structure
1TII Download structure Reference structure
1LTB Download structure Reference structure
1LTG Download structure Reference structure
1LTI Download structure Reference structure
1LTS Download structure Reference structure
1LTT Download structure Reference structure
1LTA Download structure Reference structure
1HTL Download structure Reference structure
1LT3 Download structure Reference structure
1LT4 Download structure Reference structure
Literature
  • PMID: 8478941
  • Origin

    Source: Pfam 34.0, rp75 Number of sequences: 441 Average length of the domain: 158 aa HMM: Model length: 264 Clustering level: 80% Alignment: ClustalO Additional information: sequences longer than 50 amino acids