ART family including Escherichia coli heat-labile toxin and cholera toxin secreted by Vibrio cholerae. These toxins are composed of A and B subunits – the enzymatic activity of ADP-ribosyltransferase has the A subunit.
Escherichia coli heat-labile enterotoxin is a bacterial protein toxin with an AB5 multimer structure, in which the B pentamer (INTERPRO) has a membrane-binding function and the A chain is needed for enzymatic activity [PUBMED:8478941]. The B subunits are arranged as a donut-shaped pentamer, each subunit participating in ~30 hydrogen bonds and 6 salt bridges with its two neighbours [PUBMED:8478941]. The A subunit has a less well-defined secondary structure. It predominantly interacts with the pentamer via the C-terminal A2 fragment, which runs through the charged central pore of the B subunits. A putative catalytic residue in the A1 fragment (Glu112) lies close to a hydrophobic region, which packs two loops together. It is thought that this region might be important for catalysis and membrane translocation [PUBMED:8478941].
Name | Structure | Additional informations |
---|---|---|
2A5D | Download structure | Reference structure |
2A5G | Download structure | Reference structure |
1S5C | Download structure | Reference structure |
1S5B | Download structure | Reference structure |
1S5D | Download structure | Reference structure |
1S5F | Download structure | Reference structure |
1S5E | Download structure | Reference structure |
2A5F | Download structure | Reference structure |
1XTC | Download structure | Reference structure |
1TII | Download structure | Reference structure |
1LTB | Download structure | Reference structure |
1LTG | Download structure | Reference structure |
1LTI | Download structure | Reference structure |
1LTS | Download structure | Reference structure |
1LTT | Download structure | Reference structure |
1LTA | Download structure | Reference structure |
1HTL | Download structure | Reference structure |
1LT3 | Download structure | Reference structure |
1LT4 | Download structure | Reference structure |
Source: Pfam 34.0, rp75 Number of sequences: 441 Average length of the domain: 158 aa HMM: Model length: 264 Clustering level: 80% Alignment: ClustalO Additional information: sequences longer than 50 amino acids