ART Database

A bacterial ART family. This includes nicotinic adenine dinucleotide glycohydrolases (NGA) from Streptococcus pyogenes.

This family consists of several bacterial nicotine adenine dinucleotide glycohydrolase (NGA) proteins which appear to be specific to Streptococcus pyogenes. NAD glycohydrolase (NADase) is a potential virulence factor. Streptococcal NADase may contribute to virulence by its ability to cleave beta-NAD at the ribose-nicotinamide bond, depleting intracellular NAD pools and producing the potent vasoactive compound nicotinamide [PUBMED:10979908].

Download HMM model

Source: Pfam 34.0, rp75 Number of sequences: 30 Average length of the domain: 160 aa HMM: Model length: 442 Clustering level: 80% Alignment: ClustalO Additional information: sequences longer than 50 amino acids