ART Database

A family of bacterial and viral ADP-ribosyltransferases of bi-glutamic acid.

ADP-ribosylation is a posttranslational modification of proteins involving the addition of one or more ADP-ribose moieties [PUBMED:17161604, PUBMED:10712584]. These reactions are involved in cell signalling and the control of many cell processes, including DNA repair and apoptosis [PUBMED:15003268, PUBMED:12727863]. This entry represents an ADP-ribosyltransferase domain found in various proteins, including bacterial and viral toxins such as ExoS and ExoT from Pseudomona aeruginosa which contain a C-terminal ADP-ribosyltransferase (ADPRT) domain [PUBMED:30232373].

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Source: Pfam 34.0, rp75 Number of sequences: 724 Average length of the domain: 155 aa HMM: Model length: 233 Clustering level: 80% Alignment: ClustalO Additional information: sequences longer than 50 amino acids

• DNA metabolism
• NAD+ ADP-ribosyltransferase
• chromatin architecture
• DNA repair
• ADP-ribosyltransferase
• homo sapiens
• poly(ADP-ribose) polymerases
• eukaryotes
• human
• poly(ADP-ribose)
• polymerase
• DNA damage