astARTe Database

The astARTe database is a source of information on ADP-ribosyltransferases (ARTs), common enzymes involved in post-translational modifications (PTMs). The astARTe database uses a hierarchical classification of ART families based on the presence of amino acids in the active site, and families found to be homologous are grouped into clades. The division of the ART superfamily into clades was proposed by Aravind et al . (2015) distinguishing 3 major clades based on the presence of three types of active site motif:

• HYE (histidine, tyrosine and glutamic acid),
• RSE (arginine, serine and glutamic acid),
• HHh (two histidine and hydrophobic amino acids).

There are also "atypical" clades, which do not have any of the above-mentioned versions of the active site motif.
A summary page describing a particular family of ADP-ribosyltransferases can be reached by using the Browse database or Search database (by name, ID or keywords).

For each family, a summary page is available that includes the classification and characteristics of the ADP-ribosyltransferase family and offers the ability to download sequences, matches, HMMs, logos, structures/models if known. In addition, literature references and links to external databases are available, e.g., Pfam, InterPro and others.