KINtaro Database
FAMILY: NleH (PKLF000063)
Description
NleH1, NleH2 and OspG are highly conserved T3SS effectors. These effectors possess a conserved kinase domain. NleH1 and NleH2 are found in both enteropathogenic E. coli. These effectors possess a Ser/Thr kinase domain and a PDZ-binding motif, and their main role is to block apoptosis during infection [PMID: 22123833]. OspG is secreted by pathogenic Shigella flexneri. It is known to target and regulate the host innate immune system, specifically the NF-κB signaling pathway, which plays a crucial role in inflammatory and immune responses [PMID: 29777720].
Origin
phmmer: 0.0001;
database: nr;
sequence_cutoff: 100aa;
clustering: cdhit: 90%;
catalytic residues: based on - collapsed family logo, PDB (4LRK), PMID: 24373767
Structure
PKL domain
HMM Model
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Sequences
Aligned domain sequences
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Unaligned domain sequences
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Full sequences
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Description
NleH1, NleH2 and OspG are highly conserved T3SS effectors. These effectors possess a conserved kinase domain. NleH1 and NleH2 are found in both enteropathogenic E. coli. These effectors possess a Ser/Thr kinase domain and a PDZ-binding motif, and their main role is to block apoptosis during infection [PMID: 22123833]. OspG is secreted by pathogenic Shigella flexneri. It is known to target and regulate the host innate immune system, specifically the NF-κB signaling pathway, which plays a crucial role in inflammatory and immune responses [PMID: 29777720].
Origin
phmmer: 0.0001; database: nr; sequence_cutoff: 100aa; clustering: cdhit: 90%; catalytic residues: based on - collapsed family logo, PDB (4LRK), PMID: 24373767
Structure
PKL domain
HMM Model
WebLogo