KINtaro Database

SidJ is a pseudokinase with glutamylase activity that is found in Legionella pneumophila, a bacterium responsible for causing Legionnaires' disease. Pseudokinases are a class of enzymes that resemble protein kinases but lack the ability to phosphorylate substrates. Instead, SidJ acts as a glutamylase, modifying target proteins by adding glutamate residues to specific amino acid residues. One of the key targets of SidJ's glutamylase activity is Legionellas SidE. The polyglutamylation of SidE by SidJ leads to the inactivation of the ubiquitin ligase activity of SidE. This modification is crucial for the successful replication of Legionella within a viable eukaryotic host cell [PMID: 31123136].

phmmer: 0.0001; database: nr; sequence_cutoff: 100aa; clustering: cdhit: 90%; catalytic residues: based on - collapsed family logo, 3D structure model, PDB (6OQQ), PMID: 31123136

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