KINtaro Database
FAMILY: Lcin_0519 (PKLF000046)
Description
A novel predicted family of PKL, the Lcin_0519 kinase-MTase protein and its genomic neighbors can be predicted to be related to the modification of the bacterial outer membrane, e.g., Lcin_0519 might modify LPS through phosphorylation and methylation. Lcin_0519 is annotated bioinformatically as an effector, it has not to our knowledge been studied experimentally. Thus, it can be speculated that Lcin_0519 may be not an effector, but indeed a “household” enzyme involved in the synthesis of LPS. In Legionellas it is known to be unique in comparison to most Gram-negative bacteria, highly variable between strains and species, and essential for infectivity. Lcin_0519 may be therefore acting on the Legionella envelope and contributing to pathogenicity by adjusting envelope-host cell interactions to the requirements of the infection stage [PMID: 36526881].
Origin
phmmer: 0.0001;
database: nr;
sequence_cutoff: 100aa;
clustering: cdhit: 90%;
catalytic residues (predicted only): based on - collapsed family logo, 3D structure model, HHpred, FATCAT structural pairwise alignment with 1ATP, 6PWD and 1O6Y, PMID: 36526881
HMM Model
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Sequences
Aligned domain sequences
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Unaligned domain sequences
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Full sequences
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Description
A novel predicted family of PKL, the Lcin_0519 kinase-MTase protein and its genomic neighbors can be predicted to be related to the modification of the bacterial outer membrane, e.g., Lcin_0519 might modify LPS through phosphorylation and methylation. Lcin_0519 is annotated bioinformatically as an effector, it has not to our knowledge been studied experimentally. Thus, it can be speculated that Lcin_0519 may be not an effector, but indeed a “household” enzyme involved in the synthesis of LPS. In Legionellas it is known to be unique in comparison to most Gram-negative bacteria, highly variable between strains and species, and essential for infectivity. Lcin_0519 may be therefore acting on the Legionella envelope and contributing to pathogenicity by adjusting envelope-host cell interactions to the requirements of the infection stage [PMID: 36526881].
Origin
phmmer: 0.0001; database: nr; sequence_cutoff: 100aa; clustering: cdhit: 90%; catalytic residues (predicted only): based on - collapsed family logo, 3D structure model, HHpred, FATCAT structural pairwise alignment with 1ATP, 6PWD and 1O6Y, PMID: 36526881
HMM Model
WebLogo