KINtaro Database
FAMILY: SelO (PKLF000038)
Description
SelO pseudokinase displays a protein kinase-like fold, with ATP flipped in the active site, thus providing a structural basis for catalysis. SelO are localized to the mitochondria and AMPylate proteins involved in redox homeostasis. SelO activity plays a crucial role in the cellular response to oxidative stress [PMID: 30270044].
Origin
phmmer: 0.0001;
database: nr;
sequence_cutoff: 100aa;
clustering: cdhit: 90%;
catalytic residues: UNUSUAL (SelO pseudokinase lacks the catalytic Asp (PKA D166)), based on - collapsed family logo, 3D structure model, HHpred, PDB(6EAC), PMID: 30270044
Structure
PKL domain
HMM Model
WebLogo
×
![]()
Sequences
Aligned domain sequences
Download sequence
Unaligned domain sequences
Download sequence
Full sequences
Download sequence
Description
SelO pseudokinase displays a protein kinase-like fold, with ATP flipped in the active site, thus providing a structural basis for catalysis. SelO are localized to the mitochondria and AMPylate proteins involved in redox homeostasis. SelO activity plays a crucial role in the cellular response to oxidative stress [PMID: 30270044].
Origin
phmmer: 0.0001; database: nr; sequence_cutoff: 100aa; clustering: cdhit: 90%; catalytic residues: UNUSUAL (SelO pseudokinase lacks the catalytic Asp (PKA D166)), based on - collapsed family logo, 3D structure model, HHpred, PDB(6EAC), PMID: 30270044
Structure
PKL domain
HMM Model
WebLogo
×
![]()