KINtaro Database
FAMILY: PIP5K (PKLF000031)
Description
PIP5K enzymes are categorized into type I, II, and III, and they are all present in this family. Catalyzing the phosphorylation of phosphatidylinositol-4-phosphate, PIP5K is responsible for the formation of phosphoinositol-4,5-bisphosphate, which serves as a precursor in the phosphoinositide signaling pathway [PMID: 8955136, PMID: 9535851].
Origin
phmmer: 0.0001;
database: nr;
sequence_cutoff: 100aa;
clustering: cdhit: 90%;
catalytic residues: based on - PMID: 9660759
Structure
PKL domain
HMM Model
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Sequences
Aligned domain sequences
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Unaligned domain sequences
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Full sequences
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Description
PIP5K enzymes are categorized into type I, II, and III, and they are all present in this family. Catalyzing the phosphorylation of phosphatidylinositol-4-phosphate, PIP5K is responsible for the formation of phosphoinositol-4,5-bisphosphate, which serves as a precursor in the phosphoinositide signaling pathway [PMID: 8955136, PMID: 9535851].
Origin
phmmer: 0.0001; database: nr; sequence_cutoff: 100aa; clustering: cdhit: 90%; catalytic residues: based on - PMID: 9660759
Structure
PKL domain
HMM Model
WebLogo
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![]()