KINtaro Database
FAMILY: PI3_PI4_kinase (PKLF000029)
Description
Phosphoinositide 3-kinases (PI 3-kinases or PI3Ks) are enzymes capable of phosphorylating the 3' position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). These enzymes produce various 3-phosphorylated phosphoinositides, including PtdIns(3)P, PtdIns(3,4)P2, PtdIns(3,5)P2, and PtdIns(3,4,5)P3. These phosphoinositides play a crucial role in recruiting an assorted group of signaling proteins to various cellular membranes. This mechanism involves the interaction of these phosphoinositides with different phosphoinositide-binding domains [PMID: 1322797, PMID: 1322797].
Origin
phmmer: 0.0001;
database: nr;
sequence_cutoff: 100aa;
clustering: cdhit: 90%;
catalytic residues: based on - collapsed family logo, 3D structure model, PDB (6ZWO), FATCAT structural pairwise alignment with 6ZWO, 1ATP, 1O6Y and 6PWD, PMID: 33158864
Structure
PKL domain
HMM Model
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Sequences
Aligned domain sequences
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Unaligned domain sequences
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Full sequences
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Description
Phosphoinositide 3-kinases (PI 3-kinases or PI3Ks) are enzymes capable of phosphorylating the 3' position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). These enzymes produce various 3-phosphorylated phosphoinositides, including PtdIns(3)P, PtdIns(3,4)P2, PtdIns(3,5)P2, and PtdIns(3,4,5)P3. These phosphoinositides play a crucial role in recruiting an assorted group of signaling proteins to various cellular membranes. This mechanism involves the interaction of these phosphoinositides with different phosphoinositide-binding domains [PMID: 1322797, PMID: 1322797].
Origin
phmmer: 0.0001; database: nr; sequence_cutoff: 100aa; clustering: cdhit: 90%; catalytic residues: based on - collapsed family logo, 3D structure model, PDB (6ZWO), FATCAT structural pairwise alignment with 6ZWO, 1ATP, 1O6Y and 6PWD, PMID: 33158864
Structure
PKL domain
HMM Model
WebLogo