KINtaro Database
FAMILY: Kdo (PKLF000023)
Description
The Kdo kinase domain plays a critical role in the biosynthesis of lipopolysaccharides (LPS) by phosphorylating LPS precursor - 3-deoxy-D-manno-octulosonic acid (Kdo) [PMID: 10531340]. The family of Kdo kinases also include the LPS core heptose(I) kinase rfaP. This kinase is encoded by the waaP (rfaP) gene. LPS core heptose(I) kinase rfaP plays a crucial role in adding phosphate to the O-4 position of the first heptose residue in the inner core region of LPS. Studies have demonstrated that this kinase is essential for conferring resistance to hydrophobic and polycationic antimicrobial agents in Escherichia coli [PMID: 11069912].
Origin
phmmer: 0.0001;
database: nr;
sequence_cutoff: 100aa;
clustering: cdhit: 90%;
catalytic residues: based on - collapsed family logo, 3D structure model, PDB(6WQX) HHpred, FATCAT structural pairwise alignment with 6WQX, 1ATP, 6PWD and 1O6Y, PMID: 12021457
Structure
PKL domain
HMM Model
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Sequences
Aligned domain sequences
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Unaligned domain sequences
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Full sequences
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Description
The Kdo kinase domain plays a critical role in the biosynthesis of lipopolysaccharides (LPS) by phosphorylating LPS precursor - 3-deoxy-D-manno-octulosonic acid (Kdo) [PMID: 10531340]. The family of Kdo kinases also include the LPS core heptose(I) kinase rfaP. This kinase is encoded by the waaP (rfaP) gene. LPS core heptose(I) kinase rfaP plays a crucial role in adding phosphate to the O-4 position of the first heptose residue in the inner core region of LPS. Studies have demonstrated that this kinase is essential for conferring resistance to hydrophobic and polycationic antimicrobial agents in Escherichia coli [PMID: 11069912].
Origin
phmmer: 0.0001; database: nr; sequence_cutoff: 100aa; clustering: cdhit: 90%; catalytic residues: based on - collapsed family logo, 3D structure model, PDB(6WQX) HHpred, FATCAT structural pairwise alignment with 6WQX, 1ATP, 6PWD and 1O6Y, PMID: 12021457
Structure
PKL domain
HMM Model
WebLogo