KINtaro Database
FAMILY: Fam20 (PKLF000015)
Description
The family of Golgi casein kinase proteins includes Fam20A, Fam20B, and Fam20C, which are also known as family with sequence similarity 20 (FAM20) kinases. These kinases are involved in the phosphorylation of extracellular proteins and proteoglycans. Fam20A is a pseudokinase and activate Fam20C. Fam20B regulate proteoglycn synthesis. Fam20C phosphorylates hundreds of secreted proteins. Mutations in Fam20C have been linked to a rare genetic disorder, Raine syndrome, which is characterized by severe osteosclerosis and etopic calcifications [PMID: 29572475].
Origin
phmmer: 0.0001;
database: nr;
sequence_cutoff: 100aa;
clustering: cdhit: 90%;
catalytic residues: based on - collapsed family logo, 3D structure model, PDB(4KQA), HHpred, FATCAT structural pairwise alignment with 4KQA, 1ATP, 6PWD and 1O6Y
Structure
PKL domain
HMM Model
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Sequences
Aligned domain sequences
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Unaligned domain sequences
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Full sequences
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Description
The family of Golgi casein kinase proteins includes Fam20A, Fam20B, and Fam20C, which are also known as family with sequence similarity 20 (FAM20) kinases. These kinases are involved in the phosphorylation of extracellular proteins and proteoglycans. Fam20A is a pseudokinase and activate Fam20C. Fam20B regulate proteoglycn synthesis. Fam20C phosphorylates hundreds of secreted proteins. Mutations in Fam20C have been linked to a rare genetic disorder, Raine syndrome, which is characterized by severe osteosclerosis and etopic calcifications [PMID: 29572475].
Origin
phmmer: 0.0001; database: nr; sequence_cutoff: 100aa; clustering: cdhit: 90%; catalytic residues: based on - collapsed family logo, 3D structure model, PDB(4KQA), HHpred, FATCAT structural pairwise alignment with 4KQA, 1ATP, 6PWD and 1O6Y
Structure
PKL domain
HMM Model
WebLogo