KINtaro Database
FAMILY: DUF4135 (PKLF000011)
Description
The protein kinase-like domain PKLF000011 (DUF4135) is typically found in proteins involved in the biosynthesis of lantibiotics. In the lantibiotic nukacin ISK-1, the PKLF000011 domain is located at the N-terminus of NukM, a post-translational modification enzyme. It has been shown that the PKLF000011 domain is primarily responsible for substrate recognition and dehydration during the biosynthesis of nukacin ISK-1 [PMID: 15122889].
Origin
phmmer: 0.0001;
database: nr;
sequence_cutoff: 100aa;
clustering: cdhit: 90%;
catalytic residues (predicted only): based on - collapsed family logo, 3D structure model, HHpred, FATCAT structural pairwise alignment with 5DZT, 1ATP, 6PWD and 1O6Y, PDB (5DZT), PMID: 25971839
Structure
PKL domain
HMM Model
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Sequences
Aligned domain sequences
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Unaligned domain sequences
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Full sequences
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Description
The protein kinase-like domain PKLF000011 (DUF4135) is typically found in proteins involved in the biosynthesis of lantibiotics. In the lantibiotic nukacin ISK-1, the PKLF000011 domain is located at the N-terminus of NukM, a post-translational modification enzyme. It has been shown that the PKLF000011 domain is primarily responsible for substrate recognition and dehydration during the biosynthesis of nukacin ISK-1 [PMID: 15122889].
Origin
phmmer: 0.0001; database: nr; sequence_cutoff: 100aa; clustering: cdhit: 90%; catalytic residues (predicted only): based on - collapsed family logo, 3D structure model, HHpred, FATCAT structural pairwise alignment with 5DZT, 1ATP, 6PWD and 1O6Y, PDB (5DZT), PMID: 25971839
Structure
PKL domain
HMM Model
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