KINtaro Database
FAMILY: Choline_kinase (PKLF000007)
Description
The choline/ethanolamine kinase family includes enzymes involved in the biosynthesis of phosphatidylcholine and phosphatidylethanolamine, two major phospholipids in membranes of most eukaryotic cells. These enzymes catalyze the first step in the Kennedy pathway, which is the primary pathway for the synthesis of these phospholipids [PMID: 18489261]. The choline/ethanolamine kinases are also involved in other biological processes, including cell signaling and regulation of lipid metabolism [PMID: 28411170]. These enzymes are conserved across species, and their dysfunction has been linked to various diseases, including cancer, neurological disorders, and metabolic disorders [PMID: 15003397, PMID: 28411170, PMID: 29928787, PMID: 35957983].
Origin
phmmer: 0.0001;
database: nr;
sequence_cutoff: 100aa;
clustering: cdhit: 90%;
catalytic residues: based on - collapsed family logo, 3D structure model, HHpred, FATCAT structural pairwise alignment with 4DA5, 1ATP, 6PWD and 1O6Y, PDB(4DA5), PMID: 18489261;
Structure
PKL domain
HMM Model
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Sequences
Aligned domain sequences
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Unaligned domain sequences
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Full sequences
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Description
The choline/ethanolamine kinase family includes enzymes involved in the biosynthesis of phosphatidylcholine and phosphatidylethanolamine, two major phospholipids in membranes of most eukaryotic cells. These enzymes catalyze the first step in the Kennedy pathway, which is the primary pathway for the synthesis of these phospholipids [PMID: 18489261]. The choline/ethanolamine kinases are also involved in other biological processes, including cell signaling and regulation of lipid metabolism [PMID: 28411170]. These enzymes are conserved across species, and their dysfunction has been linked to various diseases, including cancer, neurological disorders, and metabolic disorders [PMID: 15003397, PMID: 28411170, PMID: 29928787, PMID: 35957983].
Origin
phmmer: 0.0001; database: nr; sequence_cutoff: 100aa; clustering: cdhit: 90%; catalytic residues: based on - collapsed family logo, 3D structure model, HHpred, FATCAT structural pairwise alignment with 4DA5, 1ATP, 6PWD and 1O6Y, PDB(4DA5), PMID: 18489261;
Structure
PKL domain
HMM Model
WebLogo