KINtaro Database
FAMILY: APH (PKLF000005)
Description
APH family includes a group of bacterial antibiotic resistance proteins such as aminoglycoside 3'-phosphotransferase or kanamycin kinase/neomycin-kanamycin phosphotransferase which confer resistance to various aminoglycosides by inactivating aminoglycoside antibiotics via phosphorylation [PMID: 2163618, PMID: 2167474]. In addition, this family includes homoserine kinase and is related to fructosamine kinase PKLF000016.
Origin
phmmer: 0.0001;
database: nr;
sequence_cutoff: 100aa;
clustering: cdhit: 90%;
catalytic residues: based on - collapsed family logo, 3D structure model, PDB (3I0O), FATCAT structural pairwise alignment with 3I0O, 1ATP, PMID: PMID: 20089863
Structure
PKL domain
HMM Model
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Sequences
Aligned domain sequences
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Unaligned domain sequences
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Full sequences
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Description
APH family includes a group of bacterial antibiotic resistance proteins such as aminoglycoside 3'-phosphotransferase or kanamycin kinase/neomycin-kanamycin phosphotransferase which confer resistance to various aminoglycosides by inactivating aminoglycoside antibiotics via phosphorylation [PMID: 2163618, PMID: 2167474]. In addition, this family includes homoserine kinase and is related to fructosamine kinase PKLF000016.
Origin
phmmer: 0.0001; database: nr; sequence_cutoff: 100aa; clustering: cdhit: 90%; catalytic residues: based on - collapsed family logo, 3D structure model, PDB (3I0O), FATCAT structural pairwise alignment with 3I0O, 1ATP, PMID: PMID: 20089863
Structure
PKL domain
HMM Model
WebLogo