KINtaro Database
FAMILY: Alpha_kinase (PKLF000004)
Description
The alpha-kinase family is a unique group of eukaryotic protein kinases that possess a novel catalytic domain with no detectable similarity to conventional kinases. This family includes myosin heavy chain kinases, elongation factor-2 kinaseand TRP-PLIK. The structure of the alpha-kinase domain reveals unexpected similarity to eukaryotic protein kinases in the catalytic core and to metabolic enzymes with ATP-grasp domains [PMID: 7822274, PMID: 10021370, PMID: 11389851]. Myosin heavy chain kinase A from Dictyostelium, which has a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins [PMID: 7822274]. Another member is Dictyostelium myosin II heavy chain kinase A, which has a novel protein kinase catalytic domain [PMID: 9054368]. TRP-PLIK is a bifunctional protein with kinase and ion channel activities that is also a member of the alpha-kinase family [PMID: 11161216].
Origin
phmmer: 0.0001;
database: nr;
sequence_cutoff: 100aa;
clustering: cdhit: 90%;
catalytic residues: based on - collapsed family logo, 3D structure model, PDB (4BWP), FATCAT structural pairwise alignment with 4BWP, 1ATP, PMID: 23932717
Structure
PKL domain
HMM Model
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Sequences
Aligned domain sequences
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Unaligned domain sequences
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Full sequences
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Description
The alpha-kinase family is a unique group of eukaryotic protein kinases that possess a novel catalytic domain with no detectable similarity to conventional kinases. This family includes myosin heavy chain kinases, elongation factor-2 kinaseand TRP-PLIK. The structure of the alpha-kinase domain reveals unexpected similarity to eukaryotic protein kinases in the catalytic core and to metabolic enzymes with ATP-grasp domains [PMID: 7822274, PMID: 10021370, PMID: 11389851]. Myosin heavy chain kinase A from Dictyostelium, which has a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins [PMID: 7822274]. Another member is Dictyostelium myosin II heavy chain kinase A, which has a novel protein kinase catalytic domain [PMID: 9054368]. TRP-PLIK is a bifunctional protein with kinase and ion channel activities that is also a member of the alpha-kinase family [PMID: 11161216].
Origin
phmmer: 0.0001; database: nr; sequence_cutoff: 100aa; clustering: cdhit: 90%; catalytic residues: based on - collapsed family logo, 3D structure model, PDB (4BWP), FATCAT structural pairwise alignment with 4BWP, 1ATP, PMID: 23932717
Structure
PKL domain
HMM Model
WebLogo