KINtaro Database
FAMILY: AceK_kinase (PKLF000002)
Description
AceK is a bifunctional enzyme that contains both kinase and ATP/ADP-dependent phosphatase activities in its unique active site. This enzyme is responsible for phosphorylating and dephosphorylating isocitrate dehydrogenase. It catalyzes the switch between the Krebs cycle and the glyoxylate bypass [PMID: 22889914].
Origin
phmmer: 0.0001;
database: nr;
sequence_cutoff: 100aa;
clustering: cdhit: 90%;
catalytic residues: based on - collapsed family logo, 3D structure model, PDB (3EPS), FATCAT structural pairwise alignment with 3EPS, PMID: 20505668
Structure
PKL domain
HMM Model
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Sequences
Aligned domain sequences
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Unaligned domain sequences
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Full sequences
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Description
AceK is a bifunctional enzyme that contains both kinase and ATP/ADP-dependent phosphatase activities in its unique active site. This enzyme is responsible for phosphorylating and dephosphorylating isocitrate dehydrogenase. It catalyzes the switch between the Krebs cycle and the glyoxylate bypass [PMID: 22889914].
Origin
phmmer: 0.0001; database: nr; sequence_cutoff: 100aa; clustering: cdhit: 90%; catalytic residues: based on - collapsed family logo, 3D structure model, PDB (3EPS), FATCAT structural pairwise alignment with 3EPS, PMID: 20505668
Structure
PKL domain
HMM Model
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