KINtaro Database
FAMILY: ABC1 (PKLF000001)
Description
ABC1 is an ancient family of atypical kinases, also known as ADCK, COQ8, UbiB, or AarF. These proteins have a nuclear or mitochondrial subcellular location in eukaryotes, and their exact molecular functions are not clear. However, it has been suggested that members of the ABC1 family are novel chaperonins. Yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex, while E. coli AarF is required for ubiquinone production [PMID: 1648478]. The ABC1 family is unrelated to the ABC transporter proteins and includes ABC1 from yeast and AarF from E. coli [PMID: 9422602].
Origin
phmmer: 0.0001;
database: nr;
sequence_cutoff: 100aa;
clustering: cdhit: 90%;
catalytic residues: based on - collapsed family logo, 3D structure model, PDB (4PED), FATCAT structural pairwise alignment with 4PED, 1ATP, PMID: 25498144
Structure
PKL domain
HMM Model
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Sequences
Aligned domain sequences
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Unaligned domain sequences
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Full sequences
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Description
ABC1 is an ancient family of atypical kinases, also known as ADCK, COQ8, UbiB, or AarF. These proteins have a nuclear or mitochondrial subcellular location in eukaryotes, and their exact molecular functions are not clear. However, it has been suggested that members of the ABC1 family are novel chaperonins. Yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex, while E. coli AarF is required for ubiquinone production [PMID: 1648478]. The ABC1 family is unrelated to the ABC transporter proteins and includes ABC1 from yeast and AarF from E. coli [PMID: 9422602].
Origin
phmmer: 0.0001; database: nr; sequence_cutoff: 100aa; clustering: cdhit: 90%; catalytic residues: based on - collapsed family logo, 3D structure model, PDB (4PED), FATCAT structural pairwise alignment with 4PED, 1ATP, PMID: 25498144
Structure
PKL domain
HMM Model
WebLogo